GutRx Calm+ supplement bottle with capsules for gut-brain support, featuring calming probiotics and minerals.

GutRx Calm+

Gut-brain support for a calmer mind and an easier mood.

  • Magnesium, L-theanine, and saffron for calm
  • Targets the gut-brain axis
  • Supports mood and stress resilience
  • Best taken in the afternoon or evening
$47.99

90 Day Money-Back Guarantee

  • Third-party tested
  • GMP certified facility
  • Free US shipping over $75
Description

Advanced Gut-Brain Support for Calm Focus & Emotional Balance

GutRx Calm+ is a comprehensive gut-brain axis support formula designed to help promote mental calm, emotional balance, and digestive comfort—without sedation or stimulants.

By combining targeted minerals, calming amino acids, clinically studied botanicals, neuro-supportive lipids, prebiotics, and gut-brain probiotics, Calm+ supports both the mind and the microbiome, where much of the body’s stress signaling begins.


What Makes GutRx Calm+ Different?

✔ Multi-pathway gut-brain support
✔ Helps promote calm without drowsiness
✔ Supports emotional balance and stress response
✔ Includes prebiotics + probiotics for gut signaling
✔ Enteric-coated, delayed-release capsules
✔ Non-GMO | GMP-Certified | Third-Party Tested


How GutRx Calm+ Works

(Because calm doesn’t start in the head alone)

Over 90% of serotonin and many stress-related signals originate in the gut. Stress, poor diet, and inflammation can disrupt this communication, affecting mood, focus, and digestive comfort.

GutRx Calm+ works by supporting:

  • Neurotransmitter balance

  • Gut-brain signaling

  • Inflammatory modulation

  • Microbiome stability

The result is a more grounded, resilient sense of calm—built from the inside out.


Ingredient Breakdown & Functional Benefits

🧠 Mineral & Amino Acid Support

Magnesium (as Magnesium Bisglycinate) – 100 mg (24% DV)
Supports nervous system regulation and muscle relaxation; gentle and well-tolerated.

Zinc (as Zinc Carnosine) – 15 mg (136% DV)
Supports gut lining integrity and neurological signaling, helping maintain healthy gut-brain communication.

L-Theanine – 200 mg
An amino acid known to promote relaxed focus and calm alertness without sedation.


🌸 Botanical & Lipid Calm Support

Saffron Extract (Crocus sativus) – 15 mg
(Standardized to 2% safranal; equivalent to 30 mg dried stigma)
Traditionally used to support mood balance and emotional well-being.

Palmitoylethanolamide (PEA) – 300 mg
A naturally occurring fatty acid that supports the body’s response to stress and neuroinflammation.


🌱 Prebiotic Support for the Gut-Brain Axis

Galacto-oligosaccharides (GOS) – 500 mg
Derived enzymatically from lactose; supports beneficial gut bacteria linked to mood signaling.

Fructooligosaccharides (FOS) – 250 mg
Non-GMO beet-derived prebiotic fiber that nourishes microbiota involved in neurotransmitter production.


🦠 Gut-Brain Probiotic Blend – 12 Billion CFU

Bifidobacterium rhamnosus LRa66 – 4 Billion CFU
Associated with gut-brain signaling and stress resilience.

Lactobacillus plantarum Lp18 – 4 Billion CFU
Supports digestive balance and inflammatory modulation.

Lactobacillus fermentum NMCC-14 – 2 Billion CFU
Contributes to gut barrier health and immune balance.

Bifidobacterium longum BL11 – 2 Billion CFU
Linked to emotional balance and gut comfort.


Why Enteric-Coated & Delayed-Release?

Calm+ uses plant-based HPMC enteric coating to help protect sensitive ingredients through stomach acid, ensuring delivery where gut-brain signaling occurs.


Who GutRx Calm+ Is For

✔ Individuals dealing with daily stress or mental overload
✔ Those seeking calm without sedation
✔ People with stress-related digestive discomfort
✔ Anyone interested in gut-brain axis support
✔ Users wanting a science-driven calm formula


Suggested Use

Take 2 capsules daily, preferably with food.

For best results, use consistently.


Clean Label Promise

  • 60 Delayed-Release Vegetable Capsules (30 servings)

  • Non-GMO

  • GMP-Certified Facility

  • Third-Party Tested (Eurofins)

  • Free from major allergens

Other Ingredients:
Plant-based hydroxypropyl-methylcellulose (HPMC) enteric coating


GutRx Calm+

Calm the Gut. Steady the Mind. Support the Signal Between Them.

 

How to Use

Take 2 capsules daily, preferably with food.

Shipping and Returns

Orders ship within 1 business day. Free US shipping on orders over $75. Returns accepted within 90 days.

  • Third-Party Tested
  • GMP Certified
  • Made in the USA
  • Non-GMO

What It Does for Your Gut

Real outcomes, backed by clinically studied strains.

Less Bloating

Targeted strains help reduce occasional bloating and gas so you feel lighter after meals.

Better Regularity

Supports healthy, comfortable digestion and a more predictable routine.

Immune Support

About 70% of your immune system lives in your gut. Feed it well.

Every formula, built to work
The GutRx Difference

Better digestion, every day

Our delayed-release capsules protect every ingredient through stomach acid, so it arrives where it matters most, your gut.
  • Delayed-release for gut survival
  • Clinically studied doses
  • Easy daily routine

Inside Every Dose

Every strain is included at a clinically relevant amount, and we tell you exactly why it is there.

Strain Details

Lactobacillus rhamnosus LRa66

4 Billion CFU

Supports the gut-brain axis and a balanced mood.

Lactobacillus plantarum Lp18

4 Billion CFU

Supports gut barrier integrity.

Lactobacillus fermentum NMCC-14

2 Billion CFU

Supports a balanced microbiome.

Bifidobacterium longum BL11

2 Billion CFU

Studied for stress and mood support via the gut-brain axis.

Supplement Facts
Supplement Facts
Serving Size: 2 capsules
Servings Per Container: 30
% DV
Magnesium (as Magnesium Bisglycinate) 100 mg 24%
Zinc (as Zinc Carnosine) 15 mg 136%
L-theanine 200 mg
Saffron Extract (Crocus sativus, std to 2% safranal, equiv to 30 mg dried stigma) 15 mg
Galacto-oligosaccharides (GOS) 500 mg
Fructooligosaccharides (FOS) 250 mg
Palmitoylethanolamide (PEA) 300 mg
Lactobacillus rhamnosus LRa66 4 Billion CFU
Lactobacillus plantarum Lp18 4 Billion CFU
Lactobacillus fermentum NMCC-14 2 Billion CFU
Bifidobacterium longum BL11 2 Billion CFU

† Daily Value (DV) not established. Other Ingredients: Plant-based Hydroxypropyl-methylcellulose (HPMC) enteric coating.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

We hold our supplements to a higher standard
Held to a Higher Standard

We hold our supplements to a higher standard

We test what goes in and what comes out. Every batch is screened for purity and confirmed for potency, so the strains and doses on the label are exactly what reach your gut. No fillers hiding the details, no guesswork.

  • Third-party tested for purity and potency
  • Made in a GMP-certified facility
  • Clinically studied strains at meaningful doses
  • Non-GMO and free from major allergens
Third-Party Tests
Photo of Dr. Roshini Raj, MD
Calm+ works along the gut-brain axis with ingredients like saffron, L-theanine, and magnesium. For patients whose gut symptoms flare with stress, that connection matters.

Dr. Roshini Raj, MD

Board Certified Gastroenterologist, GutRx Medical Advisor

What to Expect

A healthy gut is built over weeks, not overnight. Here is a realistic timeline.

  1. Weeks 1 to 2

    Settling In

    Your microbiome starts adjusting. Mild changes in digestion are normal as new strains colonize.

  2. Weeks 3 to 4

    Finding Rhythm

    Many customers notice less bloating and a more regular routine.

  3. Week 8 and beyond

    New Baseline

    With daily use, digestive comfort and regularity become your new normal.

Real People,
Real Results

See how GutRx fits into real daily routines.

Customer photo

Daily Digestion

Customer photo

Helps digest processed foods

Customer photo

Gas and Bloat relief

Customer photo

"I cannot recommend this more"

Try It Risk Free for 90 Days

Give your gut a full 90 days. If you do not feel a difference, we will refund your order in full. No return shipping, no hoops.

Real Results from Real Customers

Frequently Asked Questions

When should I take it?

Take it daily, with or without food. Consistency matters more than timing.

Does it need refrigeration?

No. Our strains are shelf stable and protected until they reach your colon.

How do subscriptions work?

Choose your delivery frequency at checkout. You can pause, skip, or cancel anytime from your account.

When is the best time to take Calm+?

Take 2 capsules daily, ideally in the afternoon or early evening, with food.

How soon will I feel calmer?

L-theanine can bring noticeable calm within 30 to 60 minutes, while saffron's mood benefits build over 2 to 4 weeks.

Can I take it with antidepressants?

Speak with your healthcare provider first, as saffron may interact with serotonergic medications.

Will it make me drowsy?

It supports calm rather than sedation, but avoid taking it right before demanding physical activity.